Spatial transcriptomics has become a major method for high-throughput analysis of gene expression at the current level of cells, which can directly study gene expression changes in disease cells, reveal the occurrence and development mechanism of diseases, identify potential therapeutic targets related to diseases, and provide new clues for disease diagnosis and treatment. Although there have been major breakthroughs in the analysis and acquisition of transcriptome data, there are still many challenges in how to effectively manage, share and utilize these valuable data resources in the study of human systemic diseases. To solve this problem, we are committed to building a spatial transcriptome database website related to human systemic diseases, aiming to provide reliable datasets related to multiple diseases, and provide certain data information and analysis results to accelerate the progress of human systemic diseases research. This paper will introduce the construction process of the database website in detail, and discuss its application prospects in disease research, with the aim of promoting further development and innovation in the field of human health. Here, Human-spa mainly includes 12 Human systems, 38 disease types, 55 datasets, and Human-Spa provides a very friendly web interface for visualization and dataset parsing. In conclusion, the construction of Human-Spa will provide a powerful tool and resource platform for Human disease research.